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Pulmolines
Clinical and population cohort contributing to the development and unravelling of obstructive pulmonary disease (COPD) and asthma. Cohort
Clinical and population cohort contributing to the development and unravelling of obstructive pulmonary disease (COPD) and asthma.
Pulmolines is contributing to research in the development, progression, remission, and treatment of lung diseases and helps to unravel the underlying mechanisms of airway obstruction, emphysema, allergies, and airway hyperresponsiveness.
The Pulmolines cohort is the overarching cohort structure of the Groningen Research Institute for Asthma and COPD (GRIAC). The mission of GRIAC is the multidisciplinary translational study of obstructive airway and pulmonary diseases and healthy ageing.
Pulmolines aims to:
- Identify risk factors for the development, progression, and remission of lung disease;
- Identify disease-related genes, gene pathways, gene functionality, and gene regulation;
- Unravel the pathophysiology of allergen-, environmental- and smoke-induced disease in humans, animal models, and in vitro cell systems;
- Unravel the effects of disease-related inflammation on lung function, hyperresponsiveness, and small and large airway remodelling;
- Definine new targets for drug intervention and evaluation of intervention strategies;
- Develop non-invasive or less invasive tools to assess disease severity and treatment effects.
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Patients with asthma, COPD and other lung diseases and their controls with normal lung function. The number of participants varies per subcohort and mounts altogether to more than 2.000 participants.
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Data include sex and age, clinical diagnosis, lung function, smoking information, and variable: BMI, allergies, medication use, pathology diagnosis, CT-scans, comorbidity, genetics/genomics, epigenomics, expression- and proteomics data.
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- UMCG department Epidemiology
- UMCG department General Practice
- UMCG department Internal medicine
- Allergology
- UMCG department Clinical Pharmacy and Pharmacology
- UMCG department Pathology and Medical Biology
- UMCG department Pulmonary Diseases and Tuberculosis
- Working group on Respiratory Insufficiency
- UMCG department Pediatric Pulmonology and Pediatric Allergy
- UMCG European Research Institute for the Biology of Ageing (ERIBA)
- Department of Molecular Pharmacology (RUG)
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Soon available
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Relevance
How Pulmolines benefits to society
Asthma and COPD are highly prevalent in the general population, and thus focusing on these two disease areas is appropriate and has a high societal relevance. Research within GRIAC is ranging from cellular models to the underlying disease models to the clinic (translational research) with transdisciplinarity as a major feature and an overarching emphasis on healthy ageing and (personalized) diagnosis and drug development. Recognizing early disease features and relevant etiologic factors contribute to options for prevention. Societal impact therefore comprises prevention as well as aiming to provide (personalized) solutions if disease is present. Recent results are highlighted in the GRIAC Annual Report.
Contact
University Medical Center Groningen (UMCG)
Pulmolines
PO Box 30.001
9700 RB Groningen
The Netherlands
Visiting address
University Medical Center Groningen
Groningen Research Institute for Asthma and COPD (GRIAC)
Room T3.260
Hanzeplein 1
9713 GZ Groningen
The Netherlands
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