Acutelines

Participants have to meet at least one of the following criteria in order to be eligible for inclusion: 

• patients in the highest and second-highest urgency triage categories (red, orange) of the Emergency Severity Index (ESI); 
• patients in the third-highest urgency triage category (yellow) of the ESI when arriving by HEMS transport; 
• patients with several specific conditions, regardless of the urgency triage category that they are in: early sepsis, shock, syncope, anaphylaxis, acute renal failure, electrolyte disturbances intoxications, COPD and asthma exacerbations, actual or suspected deep vein thrombosis or pulmonary embolism, gastrointestinal bleeding, and bleeding from any source while using vitamin K antagonists or DOACs. 

You can send a request for more information using the Request Acutelines information form.

Please visit the UMCG Research Data Catalogue for more detailed information on our data and samples. 

Samples will be collected prior to the start of treatment, as soon as possible after presentation. A deferred proxy consent procedure is in place to allow the collection of data and biomaterials before having obtained written consent. Clinical data, imaging data and biomaterials (blood, urine, faeces, and hair) will be collected. The digital infrastructure used ensures the automated capturing of all bedside monitoring data (vital parameters and electrophysiological waveforms), and the secure import of data from other sources, such as the electronic health records drawn up by the hospital staff, ambulance staff, general practitioner, the municipal registration, and the pharmacy. 

Clinical data 

• reason for admission, including signs and symptoms; 
• physical examination and vital parameters (e.g. body temperature, blood pressure, heart rate, breathing frequency); 
• general characteristics (e.g. judgment of treating physician); 
• additional results (e.g. X-ray images, scans, ultrasound scans, laboratory test results); 
• pharmacologic and non-pharmacologic treatment. 

Questionnaires 

• demographic data (e.g. age, sex, marital status, education, living situation, ethnicity); 
• family history; 
• lifestyle (e.g. smoking, alcohol consumption, illicit drug use); 
• global functioning and experienced health (e.g. EQ-5D-5L, Katz-15 scale, Piper Fatigue Scale-12, PHQ-15); 
• mood (e.g. PHQ-2, PHQ-9, GDS-15); 
• shared decision-making (e.g. PSQ-18, OPT); 
• nutrition and activity (e.g. SNAQ, MUST, SQUASH); 
• frailty, delirium and cognitive functioning (e.g. VMS frail older patients, 4-AT, 6-CIT). 

Biomaterials 

• serum; 
• citrate plasma; 
• EDTA plasma + buffy coat (DNA); 
• heparin plasma; 
• whole blood (PAXgene RNA extraction); 
• urine; 
• faeces; 
• lock of hair. 

• UMCG department Internal medicine; (Nephrology, Geriatric Medicine)
• UMCG department Medical Oncology; 
• UMCG department Hematology; 
• UMCG department Lung disease and tuberculosis (Pulmonology); 
• UMCG department Rheumatology and Clinical Immunology; 
• UMCG department Gastroenterology and Hepatology;  
• UMCG Emergency medicine (non-trauma).

Please visit Acutelines: data- en biobank voor ontstaan en behandeling van acute aandoeningen for more information about participation (in Dutch).