Translational Bionanomicro Theragenerative Medicine

How our research benefits to society

We are committed to research in areas that have a significant healthcare, societal, and industrial impact:

• Cancer nanotherapy: By nanoparticle-based chemotherapy we propose many advantages in cancer treatment, such as good pharmacokinetics, precise targeting of tumor cells, reduction of side effects, and decreasing tumor resistance to current therapies. Delivery of more complex drug molecules to the specific site of action, design of nanotherapeutics with multi-functionalities, and introduction of nano-level diagnostic carriers hold promising future applications to fill the gaps that exist in the present therapeutic domain.
• Immunotherapeutics: Our research on immunotherapy addresses the treatment of disease by activating or suppressing of immune cells. In this context, we use biomaterials to create new Immunotherapies to elicit or amplify an immune response, classified as immunostimulatory formulations, or to establish immunotherapies that reduce or suppress the immune cells, which are recognized as immunosuppressive or immunoregulatory systems. This is of interest for clinicians and pharmaceutical companies, particularly in its promise to treat various forms of cancer, autoimmune diseases, degenerative disorders, and organ damages by immune cell modulation.
• Cardio-regenerative strategies: Cardiovascular diseases are the leading cause of death globally, and myocardial infarction is one of the most occurring heart failure with, no approved therapy to decrease the size of an established heart scar. We are continuously developing alternative strategies to promote cardioprotection and repair in the infarcted heart by (nano)biomaterials in different formats, among them scaffolds, cardiac patches, and hydrogels by immunomodulation to promote the secretion of anti-inflammatory cytokines and healing biomolecules to expand regenerative responses in the damaged heart.
• Accelerated wound repair: Skin wounds represent a major healthcare problem owing to an increasing number of trauma and pathophysiological conditions. High risk of infection and chronic damage of skin in diabetic patients or those suffering from proper immunity have prompted us to find a huge demand from the healthcare system in developing wound dressing materials or the mimic the skin microenvironment through cutting edge technologies. In the forms of injectable hydrogels and patches, our formulations can stop bleeding at early stage, kill bacteria in the damaged skin, prevent the penetration of pathogens to blood circulation, and induce cell proliferation for accelerated wound healing.