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Understanding the functions and interactions of CNS cells and how perturbations therein lead to CNS disease.
To be able to modulate or restore CNS functions to the benefit of human health is of primary relevance. The number of people suffering from CNS disease is rapidly increasing and the underlying pathophysiology often poorly understood. To elucidate the mechanisms involved in these neuropathological processes, and the identification of cellular processes that are perturbed is of great importance as these are the potential points of intervention, for urgently needed therapeutic interventions.
We are characterizing microglia subtypes in relation to Alzheimer pathology. For these studies, we employ omics technologies on human CNS tissues and hiPSCs.
We are characterizing how cellular interactions change in relation to Alzheimer’s pathology. Here, we employ omics technologies on human CNS tissues, like large scale single cell gene expression profiling.
In this line of research, we want to understand how and where MS lesion emerge, and how they progress. Profiling approaches of human CNS tissues and hiPSC models are used.
Frontotemporal dementia is the second most common dementia. The underlying neurobiological pathophysiology is not well understood and the focus of this research line. Approaches used are omics-characterization of human CNS tissues.
Department of Biomedical Sciences of Cells and Systems
University Medical Center Groningen
The Section Molecular Neurobiology, Internal Zipcode FB43
Antonius Deusinglaan, 1
9700 AD Groningen, The Netherlands
Visiting address
Department of Biomedical Sciences of Cells and Systems
University Medical Center Groningen
The Section Molecular Neurobiology, Building 3215, 8th floor
Antonius Deusinglaan, 1
9713 AV Groningen, The Netherlands