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Our ongoing research themes include:
A main research line is to understand the role of the nuclear pore complex (NPC) in ageing. The NPC’s function is intimately connected to the primary hallmarks of ageing of proteins homeostasis and genome stability, and several processes underlying these hallmarks are orchestrated at NPCs. The NPC’s function is compromised in ageing and age-related aggregation pathologies, and we aim to uncover the mechanisms responsible for NPC quality control. Specifically, we aim to uncover the mechanisms that detect damaged NPCs (sensors), the destiny of damaged NPCs (fate), and the mechanisms that prevent damage to NPCs (guardians).
Proteins with intrinsically disordered domains (IDP) have the capacity to phase separate and form condensates. The nuclear pore complex is a structure that relies on IDPs for its essential function. IDPs are also prone to aggregation, and amyloid formation of IDPs is often associated with pathology, including neurodegenerative diseases. Two groups of proteins appear critical to ensure proper phase state—chaperones, preventing aggregation of disease related IDPs, and nuclear transport receptors, whose classical function is to shuttle cargo through the NPC. The central question that we will answer is how nuclear transport receptors and chaperones impact the phase transitions of IDPs in guarding the proteome against aggregation, ensuring proper NPC function, and avoiding pathogenesis.
We aim to contribute to a better understanding of the cellular ageing process in general. Here, our strategy is to ‘simply’ observe how living cells age, and to quantify new molecular and physicochemical (e.g. pH, crowding) aspects of ageing. pH and crowding are particularly interesting as phase separation sensitively depends on these parameters. For this work we rely on life-long imaging of single yeast cells in microfluidic devises and the use of fluorescent biosensors.
“Time will tell” — We design our research from the viewpoint that studying “biology in time”, which we do in ageing research, is an unbiased way to reveal fundamental knowledge; knowledge that is needed to combat age-related diseases.
2012 Anne Meinema
Postdoctoral Fellow ETH Zurich, Switserland
2015 Annemarie Kralt
Postdoctoral Fellow, ETH Zurich, Switserland
2015 Petra Popken
PRA Health Sciences, the Netherlands
2016 Justyna Laba
PRA Health Sciences, the Netherlands
2016 R. Astri Hapsari
Postdoctoral Fellow, Institut Teknologi Bandung (ITB), Indonesia
2016 Georges Janssens
Assistant Professor – Amsterdam University Medical Center, the Netherlands
2019 Irina Rempel
Postdoc PU Galenic at Novartis NTO
University Medical Center Groningen (UMCG)
European Research Institute for the Biology of Ageing (ERIBA)
PO Box 196, Internal Zip Code FA50
9700 AD Groningen
The Netherlands
Visiting address
University Medical Center Groningen (UMCG)
European Research Institute for the Biology of Ageing (ERIBA)
Antonius Deusinglaan 1, building 3226
9713 AV Groningen