The UMCG website shows YouTube videos. YouTube places cookies if you watch them. Choose ‘Rather not’ if you do not want these cookies. We also place cookies of our own. These help us improve the usability of our website.
More on our cookie policy.
To explain how health and treatment efficacy are regulated in an individual, we analyse big data generated from samples of healthy donors and patients obtained from population and patient cohorts.
We focus on complex diseases of the gastrointestinal tract such as celiac disease (CeD), inflammatory bowel disease (IBD: Crohn’s disease and ulcerative colitis), irritable bowel syndrome (IBS), non-alcoholic fatty liver disease (NAFLD), and systemic candidemia.
With a greying population in the Netherlands, the health burden of complex, immune mediated diseases of the gastro-intestinal tract is rapidly increasing. We aim to uncover how the genetic or gut microbial make-up or the environment of an individual contributes to the development of complex, immune-mediated diseases. This knowledge enables the pinpointing of novel targets for personalised prevention and treatment using either existing approved drugs (drug repurposing) or innovative (e.g. microbiome directed) treatment protocols.
We focus on the mechanisms of complex, immune-mediated diseases of the gastro-intestinal tract, but similar or identical mechanisms and factors (both genetical, microbial and environmental) are involved in other complex diseases such as type 1 diabetes (T1D), rheumatoid arthritis (RA), multiple sclerosis (MS), and others. Because of this, our research results will contribute to the understanding and treatment of complex diseases in a broader sense.
University Medical Center Groningen (UMCG)
Institute GUIDE
3GI
P.O. Box 196
9700 AD Groningen
The Netherlands