Fundamental and applied research into the emotional, cognitive, neurobiological, and psychological mechanisms of psychiatric disorders is the central focus. This includes the identification and development of markers that inform the diagnostic process, treatment selection, monitoring and treatment response.
We contribute to personalized mental health care by developing and evaluating both theory-driven and data-driven approaches for treatment selection and monitoring, aiming for the right care being given to the right patient at the right time.
The use of innovative and clinically appropriate research designs is actively encouraged, including single-case design studies (observational, SCOD; experimental, SCED) and randomized controlled trials (RCTs), as well as both quantitative and qualitative methods. These approaches are tailored to the complexity and heterogeneity of psychiatric populations.
Research on clinical innovations, such as AI-based applications and automated, patient-accessible feedback reports, is supported with explicit attention to real-world applicability, implementation within care processes, and uptake by clinicians and patients.
We promote research focused on female-specific mechanisms in psychiatry, addressing the limitations of traditionally male-oriented medical models and improving diagnostic and treatment strategies for women.
To develop more effective, personalized treatments for the various stages of psychiatric disorders, the focus is on prevention, early intervention, and tertiary treatment.
In the CCNP research programme, experts specialized in research on different stages in life collaborate. Therefore, it is possible to develop effective, personalized prevention and early intervention programmes.
The CCNP approach includes:
The CCNP programme intends to systematically apply clinical staging and profiling in clinical trials and cohort studies, as well as in daily patient care. Good integration of research/monitoring modules in the Electronic Patient Dossier (EPD) is essential to achieve this. The clinical studies also focus on innovative methods of diagnosis and treatment, such as ecological momentary assessment (EMA), Virtual Reality (VR), and the further development of a diagnostic laboratory for patients (iLab).
Researchers combine research on the effectiveness with research on the underlying mechanisms. This research, therefore, includes genetics and imaging techniques such as fMRI and EEG, as well as psychophysiological measures such as pupil dilation deconvolution, ECG, and blood/CSF biomarkers, which are also studied in the healthy population. The resulting indicators are used to predict the response to interventions. Collaborations with statisticians take place to adopt data-driven approaches.
The CCNP research programme focuses on both psychotherapeutic and cognitive interventions, as well as on biologically targeted interventions such as:
The CCNP research also focuses on combination treatments, such as psychotherapeutic treatments supported by EMA or Virtual Reality.
Collaborations take place with various departments and disciplines, including general practice medicine, nuclear medicine, neuroscience, neurology, neurosurgery, pharmacology, clinical chemistry, genetics, and statistics.
Collaborations are also being set up with other faculties at the University of Groningen, including the centre of expertise Healthwise, the Aletta Jacobs School of Public Health, the departments of Psychology, Artificial Intelligence, and Applied Linguistics, and Health Economics (a subfield of Economics).
The research conducted in the new programme will focus on the theme Brain & Cognition (previously: the Ageing Brain) and the interfaculty Research School of Behavioural and Cognitive Neurosciences (BCN).
The CCNP research group is multidisciplinary with a strong clinical signature that focuses on applications relevant to clinical care for children, adults, and the elderly. In contrast to the Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), the CCNP research group uses a more clinical and transdiagnostic approach. Some researchers may be affiliated with both programmes, depending on the subject of the research projects that they participate in.
University Medical Center Groningen (UMCG)
Institute Health in Context
CCNP - Clinical Cognitive Neuropsychiatry Research Program
P.O. Box 196
9700 AD Groningen
