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Tropical Infectious diseases and Neglected Tropical Diseases

Group
Our research group focuses on epidemiology, prevention and management of snakebite envenoming and skin-neglected tropical diseases.

Snakebite envenoming

The biggest public health crisis you have likely never heard of as mainly poor people are killed or maimed by snakebite envenoming. In collaboration with clinicians, policy makers and researchers from Rwanda, Kenya, Eswatini, Ghana and the United Kingdom, our activities  focus on epidemiology, prevention and management of snakebite envenoming.

The legacy of neglect of the issue of snakebite is clear. Up to one-third of annual global snakebite deaths occur in Sub-Saharan Africa. But the neglect includes uncounted deaths and incomplete assessment of morbidity due to snakebite. 

Our research looks at:

  • prevention of occupational risk of snakebite envenoming;
  • the burden of snakebite envenoming including epidemiology, economic impact and long term consequences/mental health;
  • the clinical management of snakebite envenoming;
  • health systems and mechanisms supporting evidence-informed decision making.

See also: video trailer to the documentary "Minutes to Die"

Taking venom from a snake
 

Neglected Tropical Diseases

A group of 20 diseases mainly prevalent in tropical areas where they affect more than 1 billion people as a consequence of the international neglect. Our research contributes to interventions against these Neglected Tropical Diseases.

Our international research activities in Buruli ulcer (Mycobacterium ulcerans) changed treatment of the disease worldwide. From a treatment consisting of frequently mutilating surgery removing the bacteria to an eight weeks treatment with antibiotics. 

Research activities on Neglected Tropical Diseases currently focus on the following topics:

  • improving the treatment of Buruli ulcer in an attempt to shorten the time to heal (see also introduction video of the topic Buruli ulcer - "WHO: Buruli ulcer - from a difficult past to a hopeful future"); 
  • epidemiology and management of scabies in outbreaks and vulnerable populations (e.g. in refugee camps and in prisons);
  • health policy analyses and integration of NTD activities.

 

Burulico Consortium car
 

Relevance

How our research benefits to society

Interventions against these Neglected Tropical Diseases directly contribute to the achievement of the Sustainable Development Goal. 

What we have achieved:

  • clinical trials changing Buruli ulcer treatment world-wide;
  • collected data on burden of snakebite envenoming and its long term consequences in Ghana and Kenya informing policy makers;
  • detected and managed large outbreaks of scabies in vulnerable population; 
  • contributed to the Kigali Declaration on Neglected Tropical Diseases; 
  • developed an extensive international network of research partners and policy makers; 
  • vice chairing the WHO working group on operational research in skin NTDs.