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Groningen University Institute for Drug Exploration (GUIDE)
We aim to fulfil unmet needs in cure and prevention, by devising and implementing the best drug treatment for individual patients. Institute
We aim to fulfil unmet needs in cure and prevention, by devising and implementing the best drug treatment for individual patients.
GUIDE enables the transition from “one size fits all” to personalized drug treatment and helps to improve the process of target finding, drug-intervention design and development, and clinical implementation of such drugs.
The remaining barriers between fundamental and applied non-clinical and clinical sciences have to be broken down and collaboration has to take place with all stakeholders in the field of drug-intervention design and development. This allows the development of personalized treatment within the next decade, which will have an actual personal and societal impact. GUIDE is a collaboration between the University Medical Center Groningen (UMCG) and the Faculty of Science and Engineering at the University of Groningen (UG).
Relevance
From "one size fits all" to "personalized treatment" in the next decade
It is best to provide each of our patients with tailor-made treatments. GUIDE covers all aspects of the drug-intervention life cycle, from its design and development to its use in daily clinical practice.
GUIDE conducts combined drug research aimed at developing an improved therapy model for every individual patient. The institute improves the processes of:
- Target finding;
- Drug-intervention design and development;
- Clinical implementation of drugs.
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GUIDE integrates omics and big data sciences to improve target finding.
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GUIDE accelerates drug design and development by using rapid drug discovery technology and advanced, more humanized methods for candidate screening and selection.
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GUIDE’s clinical implementation activities focus on:
- A new trial design;
- Methodology for accelerated regulatory approval;
- Patient empowerment;
- Improved therapeutic applications;
- Evaluation of effectiveness and safety in daily practice;
- Interventions to improve optimal drug use.
Research on small therapeutic molecules will be extended towards biopharmaceuticals, gene-based products, and interactions with lifestyle changes.
Management team
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Jos Kosterink Director at GUIDE, Professor of Hospital and Clinical Pharmacy -
Barbro Melgert Associate professor Pharmaceutical Immunology -
Udo Mulder Internist, Vascular Specialist -
Michelle Pena Research coordinator -
Gerrit Poelarends Deputy director at GUIDE, Professor of Pharmaceutical Biotechnology -
Sven van IJzendoorn Group leader, Professor of Cell Biology
Contact
University Medical Center Groningen (UMCG)
Institute GUIDE
P.O. Box 196
9700 AD Groningen
The Netherlands