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Biobank of all-comers population of patients with ST-elevation myocardial infarction (STEMI). Cohort
Biobank of all-comers population of patients with ST-elevation myocardial infarction (STEMI).
CardioLines is a prospective biobank study, having included consecutive ST-elevation myocardial infarction (STEMI) patients between 2015 and 2021. CardioLines aims to unravel pathophysiological and prognostic insights in post-STEMI left ventricular function and clinical outcomes.
CardioLines aims to:
investigate the incidence and predictors of post-STEMI mortality and ischemic events;
investigate the incidence, pathophysiology and predictors of post-STEMI heart failure;
investigate the natural course of left ventricular function post-STEMI.
1172 consecutive STEMI patients are included. This mainly includes STEMIs due to atherosclerosis, but also other types of STEMI such as MINOCA, SCAD etc.
Baseline clinical, laboratory and echocardiographic data is obtained. Follow-up data on clinical events and echocardiographic data is available and is actively being collected. At the time of the STEMI, peripheral blood samples are taken.
Classically, large STEMIs were treated untimely or inadequately resulting in a large infarction size and occurrence of heart failure with reduced ejection fraction (HFrEF). In the current era, with more optimal treatment and secondary prevention, the incidence of HFrEF has decreased, yet the incidence of heart failure with preserved ejection fraction (HFpEF) is rising. CardioLines follows the included patients in their medical status and health records. Through the taken samples at the time of STEMI, we can unravel novel biomarkers and uncover pathophysiology.
Moreover, STEMI patients remain at high risk for subsequent acute coronary syndrome, coronary revascularizations, stroke and death. CardioLines follows all STEMI patients and study the predictors of subsequent ischemic events in the current era of adequate secondary prevention.