Until a few decades ago, the focus of much anesthesia, intensive care and emergency medicine research was on short-term outcomes such as survival beyond an acute illness or procedure. As a result, short-term outcomes have generally improved significantly. An exception is survival after severe sepsis.

Our CAPE research programme seeks to reduce mortality and especially morbidity among high-risk patients undergoing emergency care, major surgery and critical care.

This requires improved understanding of the pathophysiology and pharmacology of alterations in body homeostasis that result from primary acute problems and from adverse consequences of interventions required for the primary problem.

Optimising the restoration and protection of homeostasis will allow patients suffering from injury or disease to overcome this critical episode with fewer long-lasting sequelae that could negatively influence the natural progress of healthy ageing.

Relevance

Reduce mortality and especially morbidity among high-risk patients

Recent research indicates that diagnostic, preventive and therapeutic choices made during acute care, critical care and anesthesia for perioperative and therapeutic procedures may have a significant impact on important long-term outcomes, such as long-term survival, cancer recurrence, cognitive function, post-traumatic stress disorder, renal function and the incidence of chronic pain.

In accordance with these new findings, our aims are to maintain and extend wellbeing and welfare by limiting the impact of interventions for acute and chronic problems and thus to contribute to healthy ageing.