UMCG helicopter

CAPE - Critical care, Anaesthesiology, Peri-operative and Emergency medicine

Programme
Until a few decades ago, the focus of research in the fields of critical care, anaesthesiology and emergency medicine was largely on short-term outcomes, such as survival after an acute illness or procedure. As a result, short-term outcomes have generally improved significantly, except for survival after severe sepsis. Furthermore, as outcomes have improved, health-related quality of life has become more important. And over the past years it has become evident that there is enormous variety in critically ill patients, with all sub(pheno)types having their own needs.

The CAPE research program aims to study and develop novel approaches to reduce mortality and, particularly, morbidity among high-risk, vulnerable patients undergoing major surgery and/or patients provided with emergency and/or critical care.

To achieve this, more insight is needed into the pathophysiology and pharmacology of alterations in body homeostasis resulting from acute problems, as well as the consequences of – pharmacological - interventions during emergency and critical care treatment and/or surgical procedures required to solve acute problems. This requires a multisystem approach, both in fields of research and in departments involved. CAPE members conduct research on different organs involved in multi-organ failure, and research varies from translational to epidemiological and biobank studies. Also, CAPE members have clinical interactions with a large proportion of patients treated at the UMCG. CAPE promotes existing links between researchers and aims to facilitate collaboration between researchers from different departments. CAPE aims to serve as a facilitator of essential national and international collaborations.

Research within CAPE is embedded in four distinct themes:

  • Acute organ failure and recovery: mechanisms, innovative therapies and long-term impact
  • Early detection and advanced monitoring of clinical deterioration
  • Innovation in Postgraduate Medical Education
  • Personalized pharmacology
Relevance

Reduction in mortality and, particularly, morbidity among high-risk patients

Recent research has indicated that diagnostic, preventive and therapeutic decisions made during acute care, critical care, and anaesthesia given for perioperative and therapeutic procedures may have a significant impact on important long-term outcomes, such as long-term survival, cancer recurrence, cognitive function, post-traumatic stress disorder, renal function, and the incidence of chronic pain.

In accordance with these new findings, the CAPE programme is aimed at maintaining and promoting wellbeing and welfare by reducing the impact of interventions for acute and chronic problems and, therefore, contributing to healthy ageing.

Contact

University Medical Center Groningen (UMCG)
Institute GUIDE
CAPE - Critical care, Anaesthesiology, Peri-operative and Emergency medicine
P.O. Box 196
9700 AD Groningen
The Netherlands