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In our research, we use a multi-system translational approach, since ageing, disease, drugs, trauma, and surgery can interact and mutually amplify impairments in vital organs.
Our researchers focus on:
Patients suffering from problems requiring procedures under anaesthetic care and/or chronic pain therapy can suffer from long-term side effects which can negatively influence healthy ageing. With our research, we want to optimally maintain or restore physiological homeostasis in these patients, thus improving their quality of life.
Our research areas are:
The application demonstrates the pharmacokinetics and pharmacodynamics of midazolam after intranasal administration as described by Barends et al.
It allows the user to simulate a single dose with or without top-up dose of intranasal midazolam and to evaluate the expected effects on the midazolam plasma concentrations, Bispectral Index (BIS), modified observer's assessment of alertness/sedation (MOAA/S), mean arterial pressure (MAP) and oxygen saturation (SpO2).
see also: Groningen PMX Shiny repository apps: Midazolam intranasal PKPD in healthy elderly volunteers
University Medical Center Groningen (UMCG)
Department of Anesthesiology
PO Box 30.001
9700 RB Groningen
The Netherlands
Visiting address
University Medical Center Groningen (UMCG)
Department of Anesthesiology
Hanzeplein 1
9713 GZ Groningen