Until a few decades ago, the focus of much anesthesia, intensive care and emergency medicine research was on short-term outcomes such as survival beyond an acute illness or procedure. As a result, short-term outcomes have generally improved significantly. An exception is survival after severe sepsis.

Our CAPE research programme seeks to reduce mortality and especially morbidity among high-risk patients undergoing emergency care, major surgery and critical care.

This requires improved understanding of the pathophysiology and pharmacology of alterations in body homeostasis that result from primary acute problems and from adverse consequences of interventions required for the primary problem.

Optimizing the restoration and protection of homeostasis will allow patients suffering from injury or disease to overcome this critical episode with fewer long-lasting sequelae that could negatively influence the natural progress of healthy ageing.