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Vascular Diseases, including atherosclerosis, primary vasculitis, vasculitis or vasculopathy associated with other systemic autoimmune diseases, and pulmonary arterial hypertension are vasculopathies causing life-threatening events such as stroke, blindness, myocardial infarction, renal failure, peripheral artery occlusions, aneurysms and dissections, pulmonary fibrosis, and heart failure when left untreated. In the past decades, several therapeutics for these diseases have been developed. However, for several vasculopathies there is still a large residual risk, or, even worse, limited therapeutic options that prevent life-threatening events.
These vasculopathies share similarities in terms of genetics that determine their risk, underlying mechanisms and biomarkers, and imaging techniques employed to assess their severity. We therefore aim to bring UMCG researchers on these topics together, so we can benefit from each other towards improving the understanding of these diseases and developing tools for early detection, patient stratification, and innovative future therapy.
The research groups embedded in the Vascular Medicine strive to reduce the individual and societal high burden of complex vasculopathies by uncovering mechanisms driving vascular diseases and associated complications, improving diagnosis and clinical follow-up, and improving prevention and treatment strategies.
Our research spans from basic and translational research to clinical studies addressing research priorities determined by stakeholders-including clinicians, patients, and policy partners. It integrates basic and translational immunology, vascular science, genetics, imaging, and clinical immunological, cardio-vascular and vascular surgery expertise.
The research of this new group Vascular Medicine has already delivered societal benefits through earlier diagnosis of for instance systemic vasculitis, refined risk stratification of cardiovascular diseases, and improved care pathways.