The UMCG website shows YouTube videos. YouTube places cookies if you watch them. Choose ‘Rather not’ if you do not want these cookies. We also place cookies of our own. These help us improve the usability of our website.
Since 2009 the UMCG/RUG transgenic mouse facility has generated various (conditional) knockout and transgenic mouse strains. We use state-of-the-art technologies (recombineering, CRISPR/Cas9, ES cell culture, zygote injection) to generate genetically engineered mouse models (GEMMs).
In collaboration with the researcher we can generate a set of tissue (e.g. liver) specific knockout mice (including control mice) by somatic CRISPR/Cas9-mediated genome editing. Successful gene editing will be validated in close collaboration with the researcher.
The Facility is embedded within the Department of Paediatrics.
End product: Chimeras transmitting the mutant allele
End product: Sequence verified mutant mice
End product: A set of tissue (e.g. liver) specific knockout model with a set of control mice