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Since 2009 the UMCG/RUG transgenic mouse facility has generated various (conditional) knockout and transgenic mouse strains. We use state-of-the-art technologies (recombineering, CRISPR/Cas9, ES cell culture, zygote injection) to generate genetically engineered mouse models (GEMMs).
In collaboration with the researcher we can generate a set of tissue (e.g. liver) specific knockout mice (including control mice) by somatic CRISPR/Cas9-mediated genome editing. Successful gene editing will be validated in close collaboration with the researcher.
The Facility is embedded within the Department of Paediatrics.
End product: Chimeras transmitting the mutant allele
End product: Sequence verified mutant mice
End product: A set of tissue (e.g. liver) specific knockout model with a set of control mice