For effective pharmacological treatments, the drug needs to arrive at the right location at the right time, while keeping its activity. Nanocarriers can be used to protect drugs against degradation and promote accumulation at the target site, following systemic administration.
To assure that the carriers reach the right location in the body, we fine-tune their properties. For example, nanocarriers can be modified with target recognition peptides or sequences. However, the translocation of these carriers across cellular membranes and biological barriers during their transport from the bloodstream to the actual target tissue poses major challenges.
We study the interaction between nanocarriers and biological systems, including cellular uptake mechanisms that can be both adjusted by biochemical stimulation and physical material properties. Such combined manipulations of cellular processes will optimize the drug delivery process of nanocarriers and provide new paradigm shifts in the conventional medical therapies.