Molecular Regulation of Metabolism

Metabolic Diseases and Aging

Our research is dedicated to unraveling the complex interplay between diet, lifestyle, environment, and their implications for health and disease. We specifically investigate:

• Molecular mechanisms underlying metabolic regulation
• Development of chronic metabolic diseases
• Factors affecting the aging process

Nuclear Receptors: Key Players in Metabolic Regulation

A primary area of our research revolves around Nuclear Receptors (NRs). NRs comprise a large family of ligand-activated transcription factors that mediate responses to a wide range of lipophilic signaling molecules including lipids, steroids, retinoids, hormones and xenobiotics. As sensors for these signals, they control the complex physiologic pathways and gene networks known to be important in the development of metabolic disease.

Therapeutic Potential

NRs control crucial physiological pathways and gene networks involved in metabolic diseases. The activities of NRs can be modulated by small molecules, making NRs ideal drug targets. 13% of all FDA-approved drugs target NRs, including widely prescribed medications for hyperlipidemia and insulin resistance.

Research Approaches

Our work examines the role of NRs in metabolic processes and explores their potential as therapeutic targets in treating metabolic diseases and aging. We employ diverse research methods, including:

• Genetic screens
• Mouse models
• Cell-based models
• Multi-omics analyses