The ability to regulate energy metabolism is essential for life. Nutrient sensors play a pivotal role in regulating energy metabolism: metabolic disturbances initiate chronic diseases and contribute to their complications. Development of these systems in early life is affected by nutrition and linked to the risk of metabolic disease later in life.
We strive to gain insight into the molecular mechanisms underlying deregulated metabolism in order to develop new strategies to prevent or treat metabolic diseases. We use stable isotope technologies in humans and mouse models as well as cell systems for in-depth analysis of systemic physiology.