Solving Clinical Issues with Fundamental Science
Numerous permanent biomaterials implants or temporary devices are available for the restoration or support of function, e.g. artificial hearts, prosthetic joints, dental implants and surgical meshes. Yet, all these biomaterials attract bacteria causing infections which may result in severe clinical issues that can even be lethal (sepsis). Current treatment based on antimicrobials is not sustainable, as antimicrobial resistance is developing fast, and the number of effective antimicrobials may reach a critical point within this century.
In our research programme, we bring together clinicians and fundamental scientists aiming to solve these clinical issues through fundamental research. We develop and apply advanced models to study the mechanisms of bacterial and mammalian cells adhesion to the biomaterial surfaces and their complex competing interactions. These insights help us:
- improve our understanding of the cause of biomaterial associated infections;
- find new solution to improve current biomaterial treatment or develop novel biomaterials;
- test and validate new or improved biomaterial treatments to facilitate clinical translation;
- improve the functioning and quality of life of our patients today and prepare for the future.