Solving clinical issues with fundamental science
Numerous permanent biomaterial implants and temporary devices are available for the restoration or support of function, e.g. artificial hearts, prosthetic joints, dental implants, and surgical meshes. However, these biomaterials may attract bacteria causing infections, which may result in severe clinical issues that can even be fatal (sepsis). Current treatment based on antimicrobials is not sustainable, as antimicrobial resistance is developing fast, and there may not be a sufficient number of effective antimicrobials by the end of this century.
Our research programme brings together clinicians and fundamental scientists, who aim to solve these clinical issues through fundamental research. The MBM research team develops and applies advanced models to study the mechanisms underlying bacterial and mammalian cell adhesion to the biomaterial surfaces and their complex competing interactions. These insights help us to:
- Understand the cause of biomaterial-associated infections;
- Improve current biomaterial treatment and develop novel biomaterials;
- Test and validate new or improved biomaterial treatments to facilitate translation to clinical use;
- Improve the current and future functioning and quality of life of our patients.