From Pathophysiology of Heart Failure to Personalized Therapies. Research at UMCG Cardiology is focused in four different areas. Heart Failure is one of them.

Heart Failure is a clinical syndrome with symptoms of dyspnea, fatigue and poor exercise capacity caused by structural or functional cardiac abnormalities. Patients with heart failure are very diverse with different clinical characteristics and etiologies, but their quality of life and life expectancy are generally poor.

Relevance

Novel and personalized treatment targets

Our research group studies the pathophysiology, prevention and treatment of heart failure.

We perform modern statistical and bio-informatics technology on biomarkers, proteomics, genomics and transcriptomics to gain better insights in the pathophysiology of specific forms of heart failure which should lead to novel and personalized treatment targets.

Our team consists of professors, cardiologists, fellows, post-docs, bio-informaticians and statisticians, MD-PhD students and medical students.

Identification of therapeutic targets and molecule development

We have stored many samples from different cohorts of patients with heart failure, and perform bio-informatic applications on -omics data retrieved from these samples. This leads to the identification of therapeutic targets and molecule development. In association with our experimental work, our team is involved in several drug developments programs, both in phase I, II and III.