Cancer treatment-induced neurocognitive dysfunction

By using post-mortem human brain samples, we investigate how the normal-appearing human brain responds to the tumour and its treatment. For this, we perform integrated transcriptomic and tissue analyses.

Within this line of research, we investigate the DNA damage-induced neuro-inflammatory and immune response, with a particular focus on microglia. We here make use of human brain organoids and animal models.

Genome instability and loss of proteostasis represent two primary hallmarks of ageing. However, little is known about their interaction. Here, we aim to elucidate how (radiation-induced) DNA damage can lead to proteome instability and consequent neurodegeneration. To this end, we use cellular, brain organoid and animal models.

Although proton therapy is increasingly being used, little is known about the response of the brain at the cellular level to protons compared to standard photons used in conventional radiotherapy. This line of research is particularly relevant for paediatric brain tumour patients, who are largely treated with proton therapy.

To optimally use modern radiotherapy technologies, such as proton therapy, it is essential to understand how different brain regions respond to radiation and contribute to neurocognitive outcome. For this, we have collaborative projects that include both pre-clinical and clinical data.