TransplantLines Biobank and Cohort Study

TransplantLines Biobank and Cohort Study




About this study

  • Patient inclusion started in 2015 and is ongoing. At the time of writing (February 2021), more than 1,250 kidney transplant, 300 lung transplant, 500 liver transplant, 100 heart transplant, and 10 small bowel transplant recipients have been included in the study. A large proportion of these patients (approximately 50 to 80%, depending on the cohort involved) had undergone transplantation at least one year prior to the time of inclusion. These patients will have a single visit. The remaining patients (approximately 20 to 50%, depending on the cohort involved) were included before or shortly after transplantation. This group will have multiple visits, i.e. before transplantation and at 3 months, 6 months, 1 year, 2 years, and 5 years after transplantation.

    In addition to organ transplant recipients, we have currently (February 2021) also included more than 800 actual and potential living kidney donors. We have recently started including actual and potential living liver donors as well. These study participants will have visits during the screening process (before donation), at the time of donation, and at 3 months, 5 years, and 10 years after organ donation.


  • Prior to the visits, participants are invited to fill in a set of questionnaires on multiple topics, including socioeconomic status, quality of life, physical activity, side effects of and adherence to immunosuppressive therapy, and food frequency. Whole blood, serum, EDTA plasma, citrate plasma, heparin plasma, 24-hour urine, hair, nails, and stools are collected on the day of the visit and stored in the TransplantLines biobank for future analyses. During visits, the participants perform several physical function tests and neurocognitive tests that provide insight into the functioning of patients as well as the side-effects of immunosuppressive drugs, such as polyneuropathy and tremors.

    In addition to these samples and tests, depending on the type of transplantation, tissue samples of, for instance, skin, adipose tissue, ureter, arteries, veins, trachea, explanted livers, and lungs are collected at the time of transplantation. Samples are also collected during kidney biopsies in kidney transplant recipients, during protocol biopsies, and in case of suspected rejection.

  • Inclusion is still ongoing, which means that more patients will be included in the coming years. As a result, the patient numbers and available data will depend on the population, time interval, and the specific research questions involved. Therefore, we recommend you contact us if you are considering using data or biomaterials from the TransplantLines study. Data and biomaterials can be made available on request, after approval has been obtained from the TransplantLines Research Committee.

  • Patient information: read more about the VALIDITHI study (in Dutch)


Stephan Bakker
Stephan Bakker Professor of Internal Medicine

Contact us for data requests

Send an email  
Phone: +31 50 361 9710

Postal address

GTC (TransplantLines) – AB17
P.O. Box 30.001
9700RB Groningen
The Netherlands

Visitors address

University Medical Center Groningen
Zusterhuis, Entrance number 27.