Many patients with a primary infected aneurysm or a vascular graft infection die or experience serious and long-term complications after surgery. With the results of this study, we expect to be able to diagnose infections earlier in primary infected aneurysms and/or vascular graft infections (VGI) and to treat them more effectively. In addition, we prevent misdiagnosis by generating more attention for this problem.
Two biological xenograft materials with the potential to be infection resistant are studied in this research line.
First, the Omniflow® II biosynthetic prosthesis is evaluated in a multicenter cohort study including five medical centers from the Netherlands. This prosthesis consists of an ovine-derived collagen tube that is induced by subcutaneously implanting a polyester mesh endoskeleton into a sheep for several weeks. Hereafter it is explanted and made acellularized. The first study on this prosthesis focuses on using Omnifllow® II for replacement surgery of infected vascular graft and endografts. Another study focuses on the use of Omniflow® II for different indications in different peripheral positions, including femoral interposition, femoro-femoral crossover, femoro-popliteal, and femoro-crural.
The other xenograft that is studied in this research line is the bovine pericardial patch (BPP) used for carotid endarterectomy with patch angioplasty. Currently there is still insufficient data to recommend BPP above other patches for carotid endarterectomy. Therefore, current recommendations state that the choice of patch material depends on the surgeon and the operating team. The first study in this line, on the 10-year single center results of the use of BPP and polyester for carotid endarterectomy with patch angioplasty are recently published.1 Elaborating on this article, a multicenter study with the University Medical Center Utrecht to compare the long-term outcomes of bovine pericardial, polyester, and autologous vein patches for carotid endarterectomy with patch angioplasty is currently underway.
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