We aim to improve recognition and personalized management of syncope, specifically targeting orthostatic hypotension. By utilizing advanced haemodynamic profiling and continuous blood pressure monitoring, we examine the different subtypes and their diverse clinical manifestations.

Through a comprehensive approach that includes patient history, physical examination, and blood pressure assessment, we will differentiate between neurogenic and non-neurogenic origins for tailored intervention strategies. We emphasize a systematic, individualized, approach, investigating the efficacy of non-pharmacological lifestyle modifications, counterpressure techniques and pharmacological therapy. The overarching objective is to enhance patient outcomes and promote early identification of underlying conditions for primary or secondary autonomic dysfunction, such as Parkinson's disease or associated synucleinopathies.

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  • In this research, advanced hemodynamic profiling and continuous blood pressure monitoring are used to investigate the different subtypes of syncope and their diverse clinical manifestations. This aligns with the theme of early diagnosis, as it promotes the early recognition of orthostatic hypotension and its underlying causes. By using detailed patient histories, physical examinations, and blood pressure measurements, the research can contribute to the development of screening tools and diagnostic tests that can be employed in emergency care and pre-hospital settings. This can improve patient triage and develop care pathways that enhance the efficiency of healthcare.

  • The research focuses on a systematic, individualized approach to syncope, distinguishing between neurogenic and non-neurogenic causes to develop tailored intervention strategies. By investigating the effectiveness of non-pharmacological lifestyle modifications, counterpressure techniques, and pharmacological therapy, this study closely aligns with the personalized medicine research line. Identifying individual factors that predict responses to therapy can contribute to the development of clinical decision support tools, resulting in better personalized treatments for patients with syncope.

  • This research aims to minimize the long-term impact of orthostatic hypotension and improve the quality of life for patients. By focusing on the early identification of underlying conditions, such as Parkinson's disease or related synucleinopathies, it examines the impact of acute illnesses on health and survival after discharge. This aligns with the theme of identifying risk factors for acute diseases and developing preventive measures to reduce the likelihood of recurrence. The research contributes to societal relevance by enhancing the long-term quality of life for patients.