My name is Thiecla Katiane O. Rosales. I obtained a bachelor's degree in nutrition and a Ph.D. in Science from the Faculty of Pharmaceutical Sciences at the University of São Paulo-USP, Brazil. During my doctorate, I developed a new methodology to nanoencapsulate plant bioactive compounds, such as anthocyanins, to improve stability and intestinal delivery.
Then, I pursued a postdoctoral research fellowship at the Institute for Energy and Nuclear Research-lPEN, where I developed in vivo studies on the bioavailability of nanoencapsulated polyphenolic compounds and established a new methodology for radiolabeled molecules for bioavailability studies. Additionally, I received an award from Research Support Foundation in Sao Paulo (FAPESP) at USP to study oral therapy for cancer, aiming to identify nanoformulations based on bioactive anticancer properties for add-on treatments.
My MSCA-PF project at the University Medical Center Groningen-UMCG represents an excellent opportunity to conduct leading-edge research. I aim to investigate innovative drug nanodelivery strategies to enhance therapeutic applications, focusing on developing nanoformulations based on flavonoid compounds.
Under the supervision of Prof. Helder A. Santos from the Department of Biomaterials and Biomedical Technology-UMCG, I will use a microfluidic platform to identify nanostructures that encapsulate flavonoids for delivery to the distal portions of the colon. I will investigate its anticancer effects through a broad preclinical approach: a spheroid, organoid, and gut-on-a-chip model. In the study, we will simulate the intestinal microenvironment to understand the impact of the nanoformulations on cancer development and progression and to prospect in vivo responses.
This project may open perspectives for new pharmaceutical nanoformulations for oral administration in intestinal cancer therapy and boost my scientific career.
You can know more details about my MSCA project in the link below:
