Research by Meng Zhang showed that factors like pore size, fiber diameter, and hydrogel stiffness affect vascularization. The study also delves into the impact of different ECM sources (e.g., skin, lung) on vascularization, with skin-derived ECM hydrogels being more effective. It suggests that mechanical properties have a more significant influence on vascularization than biochemical composition, indicating the potential of ECM selection based on origin for regenerative medicine.
Additionally, the interaction between mesenchymal cells (like fibroblasts) and ECM was explored, showing fibroblasts' ability to remodel the ECM, affecting vascularization. The research also investigates scar formation, demonstrating how ECM hydrogels with a stiffness gradient can model scarred skin, offering insights into tissue repair and regeneration.
Lastly, the study identifies specific mechanosignaling pathways in endothelial cells influenced by ECM stiffness, providing a novel understanding of how mechanical signals affect vascular structure and function. This research opens new avenues for addressing vascular abnormalities in fibrotic conditions, emphasizing the importance of ECM in regenerative medicine.
