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Enhanced C/EBPα function extends healthspan and lifespan in the African turquoise killifish
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In a joint study, the Berezikov and Calkhoven labs explored how a specific change in a gene called CEBPA affects aging and health in a small and short-lived fish species known as Nothobranchius furzeri. This change improved the function of a protein called C/EBPα, which plays a role in aging. As a result, male fish lived longer and stayed healthier as they aged.
Male African turquoise killifish

The researchers also found that the genetic change activated biological pathways linked to longer life in other animals, suggesting that the way the CEBPA gene is regulated might be a common mechanism across species. This discovery could help us better understand how aging works and how to promote healthier aging in humans.

Enhanced C/EBPα Function Extends Healthspan and Lifespan in the African Turquoise Killifish
Müller, C., Muck, J.S., Ustyantsev, K., Kortman, G., Hartung, J., Berezikov, E. and Calkhoven, C.F.