Microneedle Integrated Responsive Approach for Cancer Localized Treatment Execution during Plasmonic Photothermal Multimodal Therapy (MIRACLE)
I was awarded my PhD in Nanobiotechnology from the Academy of Scientific and Innovative Research at CSIR-Central Scientific Instruments Organisation (CSIR-CSIO), India. My doctoral research focused on nanomedicine and cancer therapeutics, with particular emphasis on the design and synthesis of metallic nanoparticles and multifunctional nanocomposites for plasmonic photothermal therapy (PPTT)-assisted multimodal cancer treatment. During my doctoral research, I developed nanoparticle-based platforms integrating PPTT, photodynamic therapy (PDT), and chemotherapy for effective multimodal cancer treatment, evaluated using breast cancer and melanoma cell lines.
Following my PhD, I was awarded the prestigious national-level WISE-Postdoctoral Fellowship, funded by the Department of Science and Technology, Government of India. As a WISE Postdoctoral Fellow at CSIR-CSIO, I continued my research on plasmonic photothermal-based platforms for localized multimodal cancer therapeutics, with a focus on improving systemic toxicity.
I have now joined the Department of Biomaterials and Biomedical Technology at UMCG as a Marie Skłodowska-Curie Postdoctoral Fellow under the supervision of Professor Hélder A. Santos. Through my MSCA-PF project (MIRACLE), I have an exceptional opportunity to further advance my research in PPTT-assisted multimodal cancer therapeutics. My research will focus on developing microneedle (MN) patches integrating PPTT, PDT and chemotherapy with stimuli-responsive, on-demand release technology for localized and controlled multimodal cancer therapy, enhancing therapeutic precision while minimizing side effects. These MN patches will enable painless and localized delivery of therapeutic agents, aiming to reduce systemic toxicity, enhance treatment efficacy, and improve patient compliance. In this project, I will conduct in vitro, ex vivo, and in vivo validations, aiming to support clinically translatable MN-based cancer therapeutics. Through this research, I aim to contribute to the EU Mission: Cancer, promoting innovative cancer treatments and improving patients’ quality of life.
You can know more details about my MSCA project in the link below:
https://cordis.europa.eu/project/id/101199787
