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Department of Pediatrics

 Committed to advance scientific research and education to shape a better future from early childhood onwards. Department
Committed to advance scientific research and education to shape a better future from early childhood onwards.
Our research groups
Our research is focused on the etiology, (early) diagnosis and pathophysiology of inherited metabolic disorders (‘inborn errors of metabolism’) and acquired, i.e., lifestyle- and age-related metabolic diseases.

 

Our Mission and Goals

We are committed to advancing the field of metabolic health through a comprehensive approach encompassing research, education, and societal impact. To achieve our mission, we have established four primary objectives:

  • Our research efforts are focused on elucidating the molecular principles underlying metabolic health and unraveling the mechanisms responsible for both inborn and acquired metabolic diseases. This dual approach allows us to:

    • Investigate the intricate molecular pathways governing metabolic processes
    • Identify key factors contributing to the development of inherited metabolic disorders
    • Explore the etiology of lifestyle-related metabolic conditions

  • We are dedicated to bridging the gap between laboratory discoveries and clinical applications. Our translational research aims to:

    • Convert novel scientific insights into improved disgnostic methodologies
    • Develop effective prevention strategies based on our research findings
    • Design innovative treatment approaches for metabolic disorders

  • Education is a cornerstone of our mission. We are committed to nurturing the next generation of biomedical professionals through:

    • Interdisciplinary learning opportunities and hands-on laboratory experiences for students and trainees
    • Academic programs that integrate cutting-edge research

  • Our ultimate goal is to contribute meaningfully to public health and well-being. We strive to:

    • Develop personalized health strategies that promote healthy aging
    • Collaborate with healthcare providers to implement research-based interventions
    • Engage with policymakers and the public to raise awareness about metabolic health

Research Focus

Inherited Metabolic Disorders
We investigate rare genetic conditions, including:

  • Cystic Fibrosis
  • Fatty Acid Oxidation Disorders
  • Glycogen Storage Diseases
  • Pediatric Cholestatic Liver Diseases

Acquired Metabolic Diseases
Research also covers lifestyle- and age-related conditions such as:

  • Cardiovascular diseases (i.e. pulmonary arterial hypertention, atherosclerosis)
  • Diabetes (type 1 and type 2)
  • Hepatocellular carcinoma
  • Hyperlipidemia
  • Non-alcoholic fatty liver disease
  • Obesity

Additional Research Areas

  • Effects of drugs and nutrition on intestinal functions and the microbiome

Research Approach

We employ a multidisciplinary strategy characterized by:

  • Use of diverse experimental systems and techniques
  • Application of state-of-the-art technologies
  • Collaboration with clinicians from Beatrix Children's Hospital and other departments
  • Partnerships with private entities to maximize societal impact

Contact

University Medical Center Groningen (UMCG)
Department of Pediatrics
Postbus 30.001
9700 RB Groningen
The Netherlands

Visiting address
University Medical Center Groningen (UMCG)
Department of Pediatrics
Hanzeplein 1
9713 GZ Groningen