Aging leads to the accumulation ot p16+ senescent cells, which drive intlammation and tissue dystunction. Using transcriptomic, proteomic, and functional analyses, we reveal marked sex-specific differences in senescent cel burden and clearance during aging. Female mice accumulate more p16+ cells, particularly in the liver, and selective elimination of these cells restores youthful molecular and functional profiles only in females. Multi-omics integration uncovers conserved mitochondrial-immune regulatory networks underlying these effects. These findings highlight sex as a critical biological variable in the response to senolytic interventions and support the development of precision senotherapeutics tailored to male and female aging.
This study was led by Yao Lin and Boshi Wang and published in Advanced Science: Integrative Omics Reveal Female-Specific Benefits of p16+ Cell Clearance in Aging Mice
