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Microbial infections are a life-threatening disease. Microorganisms are adhering to a surface, either through aggregation with each other, adhesion to tissue or to a medical implant, yielding an adaptive response. This adaptive response includes the production of an extracellular polymeric matrix, that protects biofilm bacteria against environmental attacks including antibiotics and the immune system. The biofilm mode of growth combined with the occurrence of intrinsic bacterial antimicrobial-resistance forms the basis of alarming reports predicting that antimicrobial-resistant infections will become the number one cause of human death by the year 2050.
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University Medical Center Groningen (UMCG)
Department of Biomedical Engineering
Postbus 30.001
9700 RB Groningen
The Netherlands
Visiting address
University Medical Center Groningen (UMCG)
Department of Biomedical Engineering
A. Deusinglaan 1, building 3215 13th floor, FB40
9713 AV Groningen