In the ADORABLE project, university medical centres, companies and civil society organisations are working together with financial support from NWO and Nierstichting. The project, with a budget of 2.6 million euros and a duration of five years, is led by internist-nephrologist and professor of internal medicine Martin de Borst.
By better predicting how long a donor kidney works, the research consortium aims to reduce the number of patients with kidney transplant failure by 20% and also increase the number of transplants using a kidney from a deceased donor from 500 to 550 per year by the year 2035. This will lead to shorter waiting lists, lower disease burden, reduced costs and better quality of life for patients and their loved ones.
Transplant failure is a complex problem that requires cooperation between different scientific disciplines. Within ADORABLE, besides developing prediction algorithms, there will also be a focus on the perspective of patients, healthcare providers and society. Besides academic partners UMCG, Erasmus MC, UMC Utrecht and the University of Twente, (tech) companies and organizations such as Eurotransplant and the Dutch Transplant Foundation are also involved to make the knowledge gained applicable within regular care.
Besides Martin de Borst's ADORABLE project, the PERSIMMON project, in which internist-nephrologist Jan-Stephan Sanders is involved as work package leader from the UMCG, is also starting. This project focuses on personalizing the necessary immunosuppressive treatment after transplantation to increase the effectiveness of treatment, reduce side effects (toxicity) and improve patient compliance.
