Nowadays, HIV can be well controlled with antiretroviral therapy (ART). Millions of people with HIV have been saved by ART. But ART requires life-long adherence, which is challenging for many people due to a host of factors that may prevent or hinder access. Individuals who receive ART may also experience side-effects or drug toxicities, including immune system dysfunction and chronic inflammation. There are also challenges for health systems to deliver HIV prevention and testing services to people at risk of HIV, as well as treatment, care and retention services for people living with HIV today and the millions more who will need these in the future.
Ten years ago, a global consensus emerged that a curative intervention was a high priority for people living with HIV and would be necessary to help control the HIV epidemic. A cure could overcome the limitations of ART, limit new HIV transmissions, reduce stigma and discrimination, and provide a sustainable financial solution for epidemic control.
In this webinar Remko van Leeuwen, a strategic advisor on HIV cure at Aidsfonds, will discuss the recent international advances in HIV cure research. He will present the various strategies that are proposed and that include a combination of immune activators, gene-editing, neutralizing antibodies, and therapeutic vaccines. He will present the latest data from people who have cured from HIV via bone marrow transplants, discuss what we can learn from people who manage to control their HIV infection in a natural way, and provide an update on the novel cure interventions that are currently being tested in nonhuman primate models. He will also highlight the importance of ethical implications, how to strengthen cure research in low- and middle-income settings, how to include early health technology assessments in cure research projects, how to develop novel financing strategies for conducting research and a facilitate a inclusive roll-out of cure strategies once registered, and how to ensure a meaningful engagement of communities affected by HIV, who are central to the success of any cure.
Participation is free, registration is required.