This research line focuses on understanding the mechanisms initiating and contracting inflammatory responses in course of DENV and CHIKV infections. Our objective is not only to delineate the immune-mechanisms initiated by the mono-infections but also these triggered by the epidemiologically and clinically relevant, yet understudied, co-infections.
Our efforts focus on
- The role of immune cells in controlling and exacerbating DENV pathogenesis
- The molecular immune-pathogenesis of CHIKV-mediated arthralgia/arthritis and ) the interplay of innate immune responses elicited during concurrent DENV and CHIKV infection.
This research line is coordinated by dr. Izabela Rodenhuis-Zybert.